01
What is PACVS?
Definition, symptoms, related conditions, testing and key publications.
02Mechanisms
Seven graded mechanism groups and how they reinforce one another.
03Endotypes
Four patient subgroups, each defined by its dominant mechanism.
04Biomarker alterations
Metabolic, immune and neurotransmitter changes reported in patients.
05Supplements
Individual nutraceuticals mapped to the mechanism they target.
06Videos
Lectures on autoimmunity, metabolism, micro-clots and more.
The seven mechanism groups
Every Education page is organised around the same seven groups of mechanisms, so findings, endotypes and supplements connect back to the underlying biology.
- 1Persistent viral antigenSpike protein or other viral material lingers for months and keeps the immune system engaged.
- 2Immune dysregulation & viral reactivationThe immune system stays stuck in an altered state and lets dormant viruses re-emerge.
- 3Autoimmunity: GPCR and RAS autoantibodiesAutoantibodies against receptors that control blood vessels and the autonomic nervous system.
- 4Endothelial & thrombo-inflammatory injuryDamaged vessel walls and abnormal micro-clots limit oxygen delivery to tissue.
- 5Mitochondrial & metabolic failureCells cannot sustain energy production, and exertion makes it worse.
- 6Autonomic & small-fibre nerve dysfunctionThe nerves that control heart rate, blood pressure and gut function stop working properly.
- 7Neuroinflammation & blood–brain barrierInflammation reaches the brain through a leaky barrier, producing brain fog and sickness behaviour.